Jan Gebauer et al. have shown that the enzyme PrnC is able to perform targeted halogenations on pyrrole rings. The successful production of the enzyme in E. coli and the detailed investigation of its substrate recognition are significant milestones. This discovery opens up promising possibilities for the development of new pyrrolnitrin analogues with potential antimicrobial activity. We congratulate Jan Gebauer on this achievement and are excited about the publication, which demonstrates the potential of PrnC.
The publication appeared in the journal 'Frontiers in Catalysis' at doi: 10.3389/fctls.2023.1231765.